New generation yeast

Refined version of Progut® produced by stronger hydrolysis which results in a higher content of soluble bioactive structures and thus enhanced biological responses. This gives a possibility to reduce the inclusion rates and makes the product especially suitable for challenging conditions and for ruminant applications.

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Overview — Progut® Extra

Stronger Activation

Progut® Extra is a new generation version of Progut® produced by stronger hydrolysis resulting in in higher content of soluble, bioactive structures and enhanced biological responses.

Enhanced Function

Higher content of the soluble molecular yeast structures enhances the efficacy in modulating immunity and both intestinal and ruminal microbiota.

Lower Inclusion – Same Performance boost

Offers the same customer benefits than standard Progut® at lower rate of inclusion. Enhanced efficacy makes Progut® Extra especially suitable for challenging conditions and for ruminant applications.
Benefits in Farm Animals

Molecular Key to Performance

Progut® Extra delivers the benefits of a yeast hydrolysate in a concentrated form. It improves animal performance in different conditions by efficiently activating immune protection and modulating gut microbiota. A powerful enhancer of rumen microbial fermentation resulting in improved production performance of ruminants.

  • Poultry
  • Pig
  • Young ruminants
  • Dairy cows, goats and sheep
  • Beef cattle
  • Other Species
Prevents Salmonella and E. Coli problems

• Progut® application in the last 2 weeks of production for broilers reduced Salmonella count in boot swab by almost one log compared to control.

• Progut had higher in vitro binding capacity of poultry related Salmonella and E. coli strains than the tested competing yeast products.

• Progut® reduced E. coli related mortality (salpingitis) in layers.

Improves broiler performance

• In young broilers until 14 days of age Progut® improved feed conversion ratio by 2 points, and reduced mortality by 62%.

• During the 42 days growing period, Progut® improved feed conversion ratio by 2 points.

Modulates immunity

• Supplementation of Progut® in breeder diet significantly improved immunity in chicken.

• Progut® increased the concentration of IgA in the chicken gut by 38%.

• In Eimeria challenged broilers Progut® increased secretion of interferon-gamma, but did not affect the unchallenged birds.

Solves dysbiosis or dirty eggs problems in laying hens

• Progut® alleviated chronic enteritis in layers based on the improved performance.

• Progut® reduced E. coli related dysbiosis problems and dirty eggs in layers.

PRACTICAL APPLICATION

Broilers: Starter 0.8 kg/ton, Grower 0.6 kg/ton, Finisher 0.50 kg/ton of feed

Turkeys: Starter 0.8 kg/ton, Grower 0.6 kg/ton, Finisher 0.50 kg/ton of feed

Layers: From the start until the peak of lay 0.8 kg/ton of feed

Breeders: 0.8 kg/ton of feed

• For wet litter and dirty egg problems 1.6 kg/ton of feed

• For Salmonella control before the slaughter 1.6 kg/ton of feed over the last 1–2 weeks of production

We call Progut® Extra a 3-in 1 product, for thanks to its unique hydrolysis Progut® Extra has a profound immune stimulation ability, it can bind with pathogens like E. coli and balance gut microbiota.
At weaning, immature immune and intestinal system can affect the growth and feed efficiency of the piglets. Many stress factors associated with the weaning period, such as removing from the sow, changes in the diet, adapting to a new environment, mixing of piglets from different farms also lead to an intestinal dysfunction in piglets can be associated with proliferation of enterotoxigenic E. coli and post-weaning diarrhea. Progut® Extra has a proven record of performance improvement in wean piglets by reducing the risk of diarrhea, improve feed intake and FCR. Due to the stronger hydrolysis process Progut® Extra contains relatively higher amount of sugar structures which provide an alternative binding sites to bacteria and reduces the attachment of E. coli to gut mucus. However, Progut® Extra is fastening the immunomaturation of young animals by increasing the amount of immune cells in the intestinal epithelium and by increasing immunoglobulin production.
Prevents of E. coli problems

• Reduced fecal shedding of hemolytic E. coli in challenged piglets

• Higher in vitro binding capacity of pig related E. coli strains than the tested competing yeast products

• Higher prevention of E. coli attachment to piglet ileal mucus than the tested competing yeast products

• Reduced intestinal permeability increase under E. coli challenge ex vivo

Prevents weaning diarrhea in piglets

• Reduced risk of weaning diarrhea in E. coli challenged piglets

• Reduced diarrhea in E. coli challenged piglets

Modulates immunity

• Increased antibody titers against the sheep red blood cells in weaners, and tendency to increase IgG in serum 2 weeks post-weaning

• Increased concentration of IgA and amount of CD4 and CD8 + lymphocytes in the gut

• Increased production of IP-10 cytokine (chemo-attractant) in dendritic cell model in vitro (Bioplex immunoassay)

Improves piglet performance

• Improved FCR in weaners

• Improved growth and FCR in weaners

Improves sow and litter performance

• Progut® Extra in sow feed before farrowing increased colostrum yield and fat, reduced farrowing duration, and numerically reduced pre-weaning mortality

• Progut® Extra in sow feed before farrowing numerically increased IgG in colostrum, piglet birth and weaning weights, improved litter uniformity, and reduced pre-weaning mortality

PRACTICAL APPLICATION

PIGLETS Training of immunity, prevention of weaning diarrhea problems and improvement of performance of weaned piglets

• Pre-starter and starter feeds 2 weeks post-weaning: 2 kg/t, Weaner feeds 2–5 weeks post-weaning: 1.0 kg/ton

SOWS Improvement of litter performance through improved colostrum yield and quality

• Minimum one week before farrowing until end of lactation 1-1,5 kg/ton

Progut® Extra has shown performance benefits in applications for calves, goat kids and lambs. Along with the beneficial effects in the gut Progut® Extra enhances rumen development and function.
Trains the immunity to respond better to challenges

• Progut® Extra enhanced response to bacterial and viral challenges, measured by increased amounts of bacterial and viral specific IgA in the serum of calves challenged with Hog cholera and Erysipelothrix insidiossa.

Effectively binds calf specific E. coli and Salmonella

• Progut® Extra showed an outstanding capacity to bind calf specific E. coli and Salmonella bacteria in comparison to competing yeast cell wall products.

Reduces diarrhea risk

• Progut® Extra addition in starter feed improved fecal and health scores of young calves.

Effective in beef cattle

• Progut® Extra increased feed intake and growth under stressful conditions after transportation and vaccinations.

• Progut® Extra improved growth of steers.

PRACTICAL APPLICATION

CALVES, LAMBS AND GOAT KIDS Training of immunity, prevention of diarrhea problems and improvement of performance

• Starter feeds: 1–2 kg/ton of feed; Milk replacers: 2 kg/ton

BEEF CATTLE For improving feed intake, feed efficiency and growth especially under stressful conditions

• 5–10 g/d

Enhances rumen fermentation

• Progut® has consistently increased the production of gas, microbial biomass and volatile fatty acids both in vitro and in vivo.

• Improved rumen fermentation increases the amount of protein and energy that is available for the ruminant.

Improves milk yield and feed efficiency

• Progut® has increased milk yield of dairy cows on average by 1.8 kg/d.

• It has improved milk, protein and fat yields throughout the lactation with different diets and concentrate:silage ratios.

• Progut® has increased milk yield also in dairy sheep and goats.

• Addition of Progut® in the diet has improved feed efficiency by 5–8 % in dairy cows.

Supports the immunity

• Progut® has reduced somatic cell scores in milk.

• It has accelerated recovery of cow’s immune status from calving.

APPLICATION DAIRY COWS, GOATS AND SHEEP

For improving milk yield and feed efficiency and for supporting immunity

• Cows: 10 g/d; Sheep and goats: 1 g/d

• Progut® has improved daily weight gain of steers
• Progut® has increased feed intake and growth under stressful conditions after transportation and vaccinations of beef cattle
PRACTICAL APPLICATION

For improving growth and feed efficiency of beef cattle: 5–7 g/d

We keep on developing new applications for Progut®. Contact our Area Sales Managers to learn more.

Mode of Action

A new generation yeast product

Improves rumen microbial fermentation by increasing the production of microbial biomass and volatile fatty acids, especially propionate, thus improving feed efficiency, milk yield and growth performance.

Supports the immunity of ruminants.

Trains the immunity of young animals, efficiently binds E. coli and Salmonella bacteria and beneficially modulates the gut microbiota at a low inclusion rate.

Action in the rumen

Progut® Extra has increased the production of gas, microbial biomass and short chain fatty acids, especially propionic acid in numerous in vitro simulation trials with different diets and ratios of concentrate to silage. The in vitro effects have been verified with the in vivo trials in fistulated cows. Improved rumen fermentation increases the amount of protein and energy that is available for the ruminant and thus improves feed utilization.

In the simulation trials, Progut® Extra stimulated those bacterial groups that were active at the given phase of the simulation. This may indicate Quorum Sensing signaling systems involvement in the regulation of bacterial density. Microbes can produce and release chemical signal molecules by which they communicate and regulate different physiological activities. The hypothesis is that rumen bacteria can recognize increased amount of yeast cell structures as competition and grow in number for better competence.

Action in the gut

Immunity

Progut® Extra contains several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) and has increased water-solubility for better visibility to immune receptors. It has shown to increase the recruitment of T-lymphocytes and the immunoglobulin production in the gut. Due to these functions it has enhanced the immune responses of young animals under challenge. Progut® Extra trains the immune system of young animals to cope better with the challenges.

Pathogen binding

Progut® Extra contains similar carbohydrate structures, such as mannose-rich glycoproteins, as the intestinal mucus. These structures in available form provide attachment sites for the fimbriae of pathogens, thus preventing them from attaching to intestinal mucosa. The product has shown outstanding efficacy in preventing the adherence of E. coli and salmonella to intestinal mucus.

Modulating microbiota

In addition, Progut® Extra has shown to beneficially modulate the composition of gut microbiota in sows, piglets and broilers.

Supports the immunity of ruminants

Progut® Extra has reduced somatic cell scores in dairy cows. It has also increased the IgA levels in the colostrum and accelerated recovery of cow’s immune status from calving when fed to dry cows. In calves, Progut® Extra has enhanced immune responses to bacterial and viral challenges. These immune responses can be explained by the high content of several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) which are available to immune receptors due to the unique hydrolysis process.

Progut® – the 3 in one patented yeast hydrolyzate

Published articles, monogastric animals:

Hasan, S., Junnikkala, S., Peltoniemi, O., Paulin, L., Lyyski, A., Vuorenmaa, J. and Oliviero, C. (2018) Dietary supplementation with yeast hydrolysate in pregnancy does influence colostrum yield, gut microbiota of sow and piglets after birth. In: Plos One.

Jensen, K., Damgaard, B., Andresen, L., Jørgensen, E. and Carstensen, E. (2013) Prevention of post weaning diarrhea by a Saccharomyces cerevisiae derived product based on whole yeast. In: Animal Feed Science and Technology 183: 29–39.

Kim, M., Seo, J., Yun, C. Kang, S., Ko, J. and Ha, J. (2011) Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. In: Animal 5: 953–960.

Molist, F., van Eerden E., Parmentier, H.K. and Vuorenmaa, J. (2014) Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. In: Animal Feed Science and Technology 195: 136–141.

Vaahtovuo, J., Korkeamäki, M., Munukka, E., Hämeenoja, P. and Vuorenmaa, J. (2007) Microbial balance index – a view on the intestinal microbiota. In: Livestock Science 109: 174–178.

 

Published articles, ruminants

Gaffney, D., Sheehy, M., Vuorenmaa, J. and Fahey, A. (2014) The effect of supplementing dairy cows with a hydrolyzed yeast product (ProgutRumen) on milk production and somatic cell scores (Abstract). In: Journal of Animal Science. Vol. 92, E-Suppl. 2/J. Dairy Sci. Vol. 97, E-Suppl., 789.

Kettunen, H., Vuorenmaa, J., Gaffney, D. and Apajalahti, J. (2016) Yeast hydrolysate product enhances ruminal fermentation in vitro. In: Journal of Applied Animal Nutrition 4.

Meissner, H., Henning, P. Leeuw, K-J., Hagg, F., Horn, C., Kettunen, A. and Apajalahti, J. (2014) Efficacy and mode of action of selected non-ionophore antibiotics and direct-fed microbials in relation to Megasphaera elsdenii NCIMB 41125 during in vitro fermentation of an acidosis-causing substrate. In: Livestock Science 162: 115–125.

 

Posters:

Gaffney D., Sheehy M., Vuorenmaa J., Fahey A. (2014) The effect of supplementing dairy cows with a hydrolyzed yeast product (ProgutRumen) on milk production and somatic cell scores. At: Joint Annual Meeting 2014, Kansas City, USA.

Hasan S., Junnikkala S., Peltoniemi O., Oliviero C. (2017): Dietary supplementation of pregnancy diet with yeast derivate can influence colostrum yield, colostrum composition and gut microbiota. At: Gut Health Symposium 2017, St Louis, USA.

Hasan, S., Peltoniemi, O., Vuorenmaa, J., Oliviero, C. (2019). Use of antibiotics at early age can affect the gut microbiota composition and diversity in one -week old piglets. At: 11th European Symposium of Porcine Health Management (ESPHM) 2019, Utrecht, The Netherlands. (Poster)

Hasan, S., Valkonen, E., Kettunen,H., Vuorenmaa, J. (2019). A unique hydrolyzed yeast product can prevent postweaning diarrhea in Escherichia coli-susceptible piglets. At: Symposium on Gut Health in Production of Food Animals 2019, St. Louis, USA. (Presentation, Abstract)

Molist, F., van Eerden, E., Parmentiers, H. and Vuorenmaa, J. (2014). Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. At: The 6th European Symposium on Porcine Health Management (ESPHM) 2014, Sorrento, Italy.

Oliviero C, Hasan S, Junnikkala S, Peltoniemi O. (2016) Effect of a late pregnancy diet supplemented with hydrolysed yeast on sow colostrum yield and its composition. At: European Symposium of Domestic Animal Reproduction 2016, Lisbon, Portugal.

Vaahtovuo, J., Korkeamaki, M., Munukka, E., Valaja, J., Venalainen, E., Vuorenmaa, J., Hameenoja, E. and Helander, E. (2006). Intestinal microbiota and feed design. At: the 12th European Poultry Congress 2006, Verona, Italy.

Safety & Quality

Production: Safety & Quality

Progut® Extra is produced in Nastola (Finland).

Production process grants a stable content of the bio-active compounds

Approved feed ingredient in European Union, registered in several contries

GMP+ (Nastola) and ISO certified

Strict internal and external quality control

Progut® Extra

Progres® Extra is a new and highly innovative product, developed by Suomen Rehu, for use in animal feeding. It has its roots in the Finnish forests. It is a naturally active force.