Refined version of Progut® produced by stronger hydrolysis which results in a higher content of soluble bioactive structures and thus enhanced biological responses. This gives a possibility to reduce the inclusion rates and makes the product especially suitable for challenging conditions and for ruminant applications.
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Has improved rumen microbial fermentation by increasing the production of microbial biomass and volatile fatty acids, especially propionate.(* This has contributed to improved milk yield and feed efficiency.
Supports the immunity of ruminants.
Supports the immunity of young animals, efficiently binds E. coli and Salmonella bacteria and beneficially modulates the gut microbiota at a low inclusion rate.(*
Progut® Extra has increased the production of gas, microbial biomass, and short‑chain fatty acids, especially propionic acid, in numerous in vitro simulation trials. These trials were conducted with different diets and varying concentrate‑to‑silage ratios. The in vitro effects have been verified with the in vivo trials in fistulated cows. Improved rumen fermentation increases the amount of protein and energy that is available for the ruminant and thus improves feed utilization.
In the simulation trials, Progut® Extra stimulated those bacterial groups that were active at the given phase of the simulation. This may indicate Quorum Sensing signaling systems involvement in the regulation of bacterial density. Microbes can produce and release chemical signal molecules by which they communicate and regulate different physiological activities. The hypothesis is that rumen bacteria can recognize increased amount of yeast cell structures as competition and grow in number for better competence.(*
Progut® Extra contains several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) and has increased water-solubility for better visibility to immune receptors. It has shown to increase the recruitment of T-lymphocytes and the immunoglobulin production in the gut. Due to these functions it has enhanced the immune responses of young animals under challenge. Progut® Extra trains the immune system of young animals to cope better with the challenges.
Progut® Extra contains similar carbohydrate structures, such as mannose-rich glycoproteins, as the intestinal mucus. These structures in available form provide attachment sites for the fimbriae of pathogens, thus preventing them from attaching to intestinal mucosa. The product has shown outstanding efficacy in preventing the adherence of E. coli and salmonella to intestinal mucus.
In addition, Progut® Extra has shown to beneficially modulate the composition of gut microbiota in sows, piglets and broilers.
Progut® Extra has reduced somatic cell scores in dairy cows. It has also increased the IgA levels in the colostrum and accelerated recovery of cow’s immune status from calving when fed to dry cows. In calves, Progut® Extra has enhanced immune responses to bacterial and viral challenges. These immune responses can be explained by the high content of several immune stimulating compounds (β-glucan, mannoprotein and chitin structures) which are available to immune receptors due to the unique hydrolysis process.
Progut® Extra
Progut® Extra for poultry
Progut® Extra for cattle
Progut® Extra for pigs
Progut® Extra for Aqua
Progut® Extra for horses
Progut® Extra for pets
Published articles, monogastric animals:
Hasan, S., Junnikkala, S., Peltoniemi, O., Paulin, L., Lyyski, A., Vuorenmaa, J. and Oliviero, C. (2018) Dietary supplementation with yeast hydrolysate in pregnancy does influence colostrum yield, gut microbiota of sow and piglets after birth. In: Plos One.
Jensen, K., Damgaard, B., Andresen, L., Jørgensen, E. and Carstensen, E. (2013) Prevention of post weaning diarrhea by a Saccharomyces cerevisiae derived product based on whole yeast. In: Animal Feed Science and Technology 183: 29–39.
Kim, M., Seo, J., Yun, C. Kang, S., Ko, J. and Ha, J. (2011) Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. In: Animal 5: 953–960.
Molist, F., van Eerden E., Parmentier, H.K. and Vuorenmaa, J. (2014) Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. In: Animal Feed Science and Technology 195: 136–141.
Vaahtovuo, J., Korkeamäki, M., Munukka, E., Hämeenoja, P. and Vuorenmaa, J. (2007) Microbial balance index – a view on the intestinal microbiota. In: Livestock Science 109: 174–178.
Published articles, ruminants
Gaffney, D., Sheehy, M., Vuorenmaa, J. and Fahey, A. (2014) The effect of supplementing dairy cows with a hydrolyzed yeast product (ProgutRumen) on milk production and somatic cell scores (Abstract). In: Journal of Animal Science. Vol. 92, E-Suppl. 2/J. Dairy Sci. Vol. 97, E-Suppl., 789.
Kettunen, H., Vuorenmaa, J., Gaffney, D. and Apajalahti, J. (2016) Yeast hydrolysate product enhances ruminal fermentation in vitro. In: Journal of Applied Animal Nutrition 4.
Meissner, H., Henning, P. Leeuw, K-J., Hagg, F., Horn, C., Kettunen, A. and Apajalahti, J. (2014) Efficacy and mode of action of selected non-ionophore antibiotics and direct-fed microbials in relation to Megasphaera elsdenii NCIMB 41125 during in vitro fermentation of an acidosis-causing substrate. In: Livestock Science 162: 115–125.
Posters:
Gaffney D., Sheehy M., Vuorenmaa J., Fahey A. (2014) The effect of supplementing dairy cows with a hydrolyzed yeast product (ProgutRumen) on milk production and somatic cell scores. At: Joint Annual Meeting 2014, Kansas City, USA.
Hasan S., Junnikkala S., Peltoniemi O., Oliviero C. (2017): Dietary supplementation of pregnancy diet with yeast derivate can influence colostrum yield, colostrum composition and gut microbiota. At: Gut Health Symposium 2017, St Louis, USA.
Hasan, S., Peltoniemi, O., Vuorenmaa, J., Oliviero, C. (2019). Use of antibiotics at early age can affect the gut microbiota composition and diversity in one -week old piglets. At: 11th European Symposium of Porcine Health Management (ESPHM) 2019, Utrecht, The Netherlands. (Poster)
Hasan, S., Valkonen, E., Kettunen,H., Vuorenmaa, J. (2019). A unique hydrolyzed yeast product can prevent postweaning diarrhea in Escherichia coli-susceptible piglets. At: Symposium on Gut Health in Production of Food Animals 2019, St. Louis, USA. (Presentation, Abstract)
Molist, F., van Eerden, E., Parmentiers, H. and Vuorenmaa, J. (2014). Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. At: The 6th European Symposium on Porcine Health Management (ESPHM) 2014, Sorrento, Italy.
Oliviero C, Hasan S, Junnikkala S, Peltoniemi O. (2016) Effect of a late pregnancy diet supplemented with hydrolysed yeast on sow colostrum yield and its composition. At: European Symposium of Domestic Animal Reproduction 2016, Lisbon, Portugal.
Vaahtovuo, J., Korkeamaki, M., Munukka, E., Valaja, J., Venalainen, E., Vuorenmaa, J., Hameenoja, E. and Helander, E. (2006). Intestinal microbiota and feed design. At: the 12th European Poultry Congress 2006, Verona, Italy.
Progut® Extra is produced in Nastola (Finland).
Production process grants a stable content of the bio-active compounds
Approved feed ingredient in European Union, registered in several contries
GMP+ certified
Strict internal and external quality control
*References:
– Kettunen, H., Vuorenmaa, J., Gaffney, D. and Apajalahti, J. (2016) Yeast hydrolysate product enhances ruminal fermentation in vitro. Journal of Applied Animal Nutrition 4: E1.
– Jensen, K., Damgaard, B., Andresen, L., Jørgensen, E. and Carstensen, E. (2013) Prevention of post weaning diarrhea by a Saccharomyces cerevisiae derived product based on whole yeast. Animal Feed Science and Technology 183: 29–39.
– Molist, F., van Eerden E., Parmentier, H.K. and Vuorenmaa, J. (2014) Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. Animal Feed Science and Technology 195: 136–141.
– Middekoop, A., Kettunen, H., Guan, X., Vuorenmaa, J., Tichelaar, R., Gambino, M., Rydal, M. and Molist, F. (2024) Effect of dietary tall oil fatty acids and hydrolysed yeast in SNP2‑positive and SNP2‑negative piglets challenged with F4 enterotoxigenic Escherichia coli. Scientific Reports 14:2060
– Hasan, S., Junnikkala, S., Peltoniemi, O., Paulin, L., Lyyski, A., Vuorenmaa, J. and Oliviero, C. (2018) Dietary supplementation with yeast hydrolysate in pregnancy does influence colostrum yield, gut microbiota of sow and piglets after birth. PLoS ONE 13(5)
– Oliviero C, Hasan S, Junnikkala S, Peltoniemi O. (2016) Effect of a late pregnancy diet supplemented with hydrolysed yeast on sow colostrum yield and its composition. At: European Symposium of Domestic Animal Reproduction 2016, Lisbon, Portugal.
– Kim, M., Seo, J., Yun, C. Kang, S., Ko, J. and Ha, J. (2011) Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. Animal 5: 953–960.
– Gaffney D., Sheehy M., Vuorenmaa J., Fahey A. (2014) The effect of supplementing dairy cows with a hydrolyzed yeast product (ProgutRumen) on milk production and somatic cell scores. At: Joint Annual Meeting 2014, Kansas City, USA. Abstract in: Journal of Animal Science. Vol. 92
– Savary P. 2009. Welche Wirkung hat der Einsatz der Hefeeinsatz auf die Leistungsfähigkeit von Hochleistungskühen unter Schweizer Bedingungen? Diplomarbeit Schweizerische Hochschule für Landwirtschaft.
– Pirinen, E. 2026. Hiivahydrolysaatin vaikutukset luomulehmien maidontuotantoon ja maidon solulukuun. At Maataloustieteen päivät 2026 (poster)
– Kettunen, H., Vuorenmaa, J., and Jintasataporn, O. (2024) Yeast hydrolysate improved the performance, survival rate and immunity of Whiteleg shrimp (Litopenaeus vannamei). At: Aqua 2024 Copenhagen Denmark.
– Kettunen, H., Vuorenmaa, J., and Jintasataporn, O. (2025) Dietary yeast hydrolysate improved the performance of Asian seabass (Lates calcarifer) in juvenile and grower stages. At: EAS2025.
– Valkonen, E., Kettunen, H., Hasan, S., Vuorenmaa, J., Chumkam, S., Jintasataporn, O. (2020) Saccharomyces cerevisiae -hydrolysate improved performance of Asian sea bass. Abstract 28.06 at the European Federation of Animal Science (EAAP) virtual meeting 1-4 December 2020. (Poster)
– Kim, M., Seo, J., Yun, C. Kang, S., Ko, J. and Ha, J. (2011) Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. Animal 5: 953–960.
– Molist, F., van Eerden E., Parmentier, H.K. and Vuorenmaa, J. (2014) Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. Animal Feed Science and Technology 195: 136–141.
– Al-Abdullatif, A., Alhotan, R., Al-Badwi, M-, Dong, X., Kettunen H., Vuorenmaa, J. Sakr, S. and Azzam, M. 2024. Eects of hydrolyzed yeast on growth performance, intestinal redox homeostasis, and woody breast myopathy in heat-stressed broilers. Frontiers in Veterinary Science 11:1484150.
– Hasan, S., Junnikkala, S., Peltoniemi, O., Paulin, L., Lyyski, A., Vuorenmaa, J. and Oliviero, C. (2018) Dietary supplementation with yeast hydrolysate in pregnancy does influence colostrum yield, gut microbiota of sow and piglets after birth. PLoS ONE 13(5)
– Kim, M., Seo, J., Yun, C. Kang, S., Ko, J. and Ha, J. (2011) Effects of hydrolyzed yeast supplementation in calf starter on immune responses to vaccine challenge in neonatal calves. Animal 5: 953–960.
– Molist, F., van Eerden E., Parmentier, H.K. and Vuorenmaa, J. (2014) Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. Animal Feed Science and Technology 195: 136–141.
– Al-Abdullatif, A., Alhotan, R., Al-Badwi, M-, Dong, X., Kettunen H., Vuorenmaa, J. Sakr, S. and Azzam, M. 2024. Eects of hydrolyzed yeast on growth performance, intestinal redox homeostasis, and woody breast myopathy in heat-stressed broilers. Frontiers in Veterinary Science 11:1484150.